Efficient Gene Transfer to Kidney Mesenchymal Cells Using a Synthetic Adeno-Associated Viral Vector.

Yoichiro IkedaZhao SunXiao RuLuk H VandenbergheBenjamin D Humphreys

Published in: Journal of the American Society of Nephrology : JASN (2018)

These studies establish a novel method for inducible knockout of floxed genes in mouse mesangium, pericytes, and perivascular fibroblasts and are the foundation for future gene therapy approaches to treat kidney fibrosis.

Keyphrases

gene therapy
genome wide
induced apoptosis
genome wide identification
cell cycle arrest
stem cells
sars cov
bone marrow
copy number
current status
genome wide analysis
dna methylation
signaling pathway
cell death
gene expression
pi k akt
electron transfer