PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer.

Carmen GhilardiCatarina Moreira-BarbosaLaura BrunelliPaola OstanoNicolò PaniniMonica Lupi Alessia Anastasia Fabio FiordalisoMonica SalioLaura Formenti Massimo Russo Edoardo ArrigoniFerdinando ChiaradonnaGiovanna ChiorinoGiulio DraettaJoseph R MarszalekChristopher P VellanoRoberta PastorelliMaria Rosa Bani Alessandra DecioRaffaella Giavazzi

Published in: Cancer research (2022)

OXPHOS inhibition in ovarian cancer can exploit the metabolic vulnerabilities conferred by high PGC1α/β expression and offers an effective approach to manage patients on the basis of PGC1α/β expression.

Keyphrases

poor prognosis
skeletal muscle
end stage renal disease
binding protein
newly diagnosed
chronic kidney disease
long non coding rna
peritoneal dialysis
patient reported outcomes
patient reported