Vitamin B6 and Riboflavin, Their Metabolic Interaction and Relationship With MTHFR Genotype, in Adults Aged 18-102 Years.

These results are consistent with the known metabolic dependency of PLP on FMN and suggest that riboflavin may be the limiting nutrient for maintaining vitamin B6 status, particularly in individuals with the MTHFR 677TT genotype. Randomized trials are necessary to investigate the PLP response to riboflavin intervention within the dietary range.