Oleanolic Acid Targets the Gut-Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis.
Chenyu XueYing LiHao LvLei ZhangChongpeng BiNa DongAnshan ShanJiali WangPublished in: Journal of agricultural and food chemistry (2021)
This study investigated the effects of oleanolic acid (OA) on hepatic lipid metabolism and gut-liver axis homeostasis in an obesity-related non-alcoholic fatty liver disease (NAFLD) nutritional animal model and explored possible molecular mechanisms behind its effects. The results revealed that OA ameliorated the development of metabolic disorders, insulin resistance, and hepatic steatosis in obese rats. Meanwhile, OA restored high-fat-diet (HFD)-induced intestinal barrier dysfunction and endotoxin-mediated induction of toll-like-receptor-4-related pathways, subsequently inhibiting endotoxemia and systemic inflammation and balancing the homeostasis of the gut-liver axis. OA also reshaped the composition of the gut microbiota of HFD-fed rats by reducing the Firmicutes/Bacteroidetes ratio and increasing the abundance of butyrate-producing bacteria. Our results support the applicability of OA as a treatment for obesity-related NAFLD through its anti-inflammatory, antioxidant, and prebiotic integration responses mediated by the gut-liver axis.
Keyphrases
- high fat diet
- insulin resistance
- adipose tissue
- toll like receptor
- metabolic syndrome
- type diabetes
- knee osteoarthritis
- high fat diet induced
- skeletal muscle
- anti inflammatory
- polycystic ovary syndrome
- weight loss
- immune response
- inflammatory response
- nuclear factor
- physical activity
- bariatric surgery
- obese patients
- mass spectrometry
- high resolution
- fatty acid
- microbial community
- wastewater treatment
- liver fibrosis