Evidence for inflammation in normal-appearing brain regions in patients with growing sporadic vestibular schwannoma: A PET study.
Bandar AlfaifiRainer HinzAlan JacksonAndrea WadesonOmar N PathmanabanCharlotte Hammerbeck-WardScott A RutherfordAndrew T KingDaniel LewisDavid J CoopePublished in: Neuro-oncology advances (2024)
We present the first in vivo evidence of increased TSPO expression and inflammation within the brains of patients with growing sporadic VS. These results provide a potential mechanistic insight into the development of nonauditory symptoms in these patients and highlight the need for further studies interrogating the role of neuroinflammation in driving VS symptomatology.
Keyphrases
- end stage renal disease
- oxidative stress
- late onset
- ejection fraction
- newly diagnosed
- chronic kidney disease
- poor prognosis
- traumatic brain injury
- peritoneal dialysis
- computed tomography
- prognostic factors
- cerebral ischemia
- lipopolysaccharide induced
- cognitive impairment
- multiple sclerosis
- depressive symptoms
- blood brain barrier
- binding protein
- functional connectivity
- patient reported
- subarachnoid hemorrhage
- long non coding rna