Type I Interferon-Activated STAT4 Regulation of Follicular Helper T Cell-Dependent Cytokine and Immunoglobulin Production in Lupus.
Xuemei DongOlivia Q AntaoWenzhi SongGina M SanchezKrzysztof ZembrzuskiFotios KoumpourasAlexander LemenzeJoe CraftJason S WeinsteinPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
We identified a role for type I IFN signaling in driving STAT4 activation and production of IL-21 and IFNγ by Tfh cells in murine and human lupus. Enhanced STAT4 activation in Tfh cells may underlie pathogenic B cell responses in both murine and human lupus. These data indicate that STAT4 guides pathogenic cytokine and immunoglobulin production in SLE, demonstrating a potential therapeutic target to modulate autoimmunity.
Keyphrases
- systemic lupus erythematosus
- induced apoptosis
- disease activity
- dendritic cells
- cell proliferation
- endothelial cells
- cell cycle arrest
- immune response
- induced pluripotent stem cells
- pluripotent stem cells
- endoplasmic reticulum stress
- rheumatoid arthritis
- signaling pathway
- oxidative stress
- pi k akt
- artificial intelligence
- celiac disease