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Robust enumeration of cell subsets from tissue expression profiles.

Aaron M NewmanChih Long LiuMichael R GreenAndrew J GentlesWeiguo FengYue XuChuong D HoangMaximilian DiehnAsh A Alizadeh
Published in: Nature methods (2015)
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types. CIBERSORT should enable large-scale analysis of RNA mixtures for cellular biomarkers and therapeutic targets (http://cibersort.stanford.edu/).
Keyphrases
  • single cell
  • cell therapy
  • gene expression
  • bone marrow
  • ionic liquid
  • peripheral blood
  • mesenchymal stem cells