Late isolated central nervous system relapse in childhood B-cell acute lymphoblastic leukemia treated with intensified systemic therapy and delayed reduced dose cranial radiation: A report from the Children's Oncology Group study AALL02P2.
Caroline A HastingsYichen ChenMeenakshi DevidasA Kim RitcheyNaomi J WinickWilliam L CarrollStephen P HungerBrent L WoodRobert B MarcusJulio C BarredoPublished in: Pediatric blood & cancer (2021)
COG AALL02P2 showed inferior EFS but similar OS compared to POG 9412. Limitations included a small sample size, more intensive prior therapies, and a significant number of patients (34/118, 29%) who did not receive protocol-directed radiation due to early relapse prior to 1 year or did not otherwise follow the treatment plan. New approaches are needed to improve outcome for these patients and determine the optimal timing and dose of cranial radiation in the treatment of iCNS-R.
Keyphrases
- acute lymphoblastic leukemia
- end stage renal disease
- newly diagnosed
- young adults
- randomized controlled trial
- ejection fraction
- stem cells
- palliative care
- mesenchymal stem cells
- radiation therapy
- peritoneal dialysis
- allogeneic hematopoietic stem cell transplantation
- acute myeloid leukemia
- cell therapy
- replacement therapy