Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.

Qiong YangFlorian PuhmMichael FreissmuthChristian Nanoff

Published in: Cancer chemotherapy and pharmacology (2017)

Since formation of cAMP is the first signalling step in raising water permeability of the collecting duct epithelia, we suggest that V2-receptor upregulation generates hypersensitivity to vasopressin linking HSP90 inhibition to the development of hyponatremia.

Keyphrases

heat shock protein
poor prognosis
heat shock
heat stress
cell proliferation
binding protein
signaling pathway
drug induced
acute heart failure
oxidative stress