TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma.

Glauco BaiocchiFernando Luís Visoni PoliseliLouise De BrotHenrique MantoanBeatriz Nunes SchiavonCarlos Chaves FaloppaJose VassalloFernando Augusto SoaresIsabela Werneck Cunha

Published in: Journal of clinical pathology (2016)

TOP2A is highly expressed in advanced LMS but not in non-malignant diseases. TOP2A expression does not correlate with FISH results and does not predict outcome. TOP2A levels are higher in high-mitotic index tumours and in more advanced stages of disease.

Keyphrases

copy number
smooth muscle
poor prognosis
mitochondrial dna
genome wide
binding protein
dna methylation
long non coding rna
gene expression