The use of shotgun label-free quantitative proteomic mass spectrometry to evaluate the inflammatory response in aqueous humor from horses with uveitis compared to ophthalmologically healthy horses.
Hannah M TerhaarMichala de Linde HenriksenCarolina MehaffyAnn HessRichard J McMullenPublished in: Veterinary ophthalmology (2023)
Differential abundance of A2M, prothrombin, fibrinogen, and C4 indicate upregulation of the complement and coagulation cascade in equine uveitis. Proinflammatory cytokines and the complement cascade have potential as therapeutic targets for equine uveitis.
Keyphrases
- label free
- juvenile idiopathic arthritis
- ankylosing spondylitis
- inflammatory response
- mass spectrometry
- high resolution
- disease activity
- poor prognosis
- liquid chromatography
- cell proliferation
- lipopolysaccharide induced
- signaling pathway
- antibiotic resistance genes
- ms ms
- toll like receptor
- risk assessment
- microbial community
- systemic lupus erythematosus
- immune response
- human health
- anaerobic digestion