Progressive Reduction in Right Ventricular Contractile Function Attributable to Altered Actin Expression in an Aging Mouse Model of Arrhythmogenic Cardiomyopathy.
Emmanuel M CamorsAlyson H RothJoseph R AlefRyan D SullivanJason Nathaniel JohnsonEnkhsaikhan PurevjavJeffrey A TowbinPublished in: Circulation (2022)
During the early concealed phase of ACM, reduced actin expression drives loss of RV myocyte contraction, contributing to progressive RV dysfunction.