Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD.

Jun LiangYing LiuJinguang LiuZhe LiQiangyuan FanZifei JiangFei YanZhi WangPeiwen HuangNianping Feng

Published in: Journal of nanobiotechnology (2018)

CS-LPNs enhanced oral delivery of silymarin and exhibited a desirable lipid-lowering effect in a mouse model. These findings suggest that CS-LPNs may be a promising oral nanocarrier for NAFLD therapeutics.

Keyphrases

mouse model
drug delivery
fatty acid
small molecule
quantum dots
hyaluronic acid
solid phase extraction