Sperm DNA methylation dynamics after chemotherapy: A longitudinal study of a patient with testicular germ cell tumor treatment.

The consequences of cancer treatment on the sperm epigenome during the recovery periods are topical issues of increasing significance as epigenetic modifications to the paternal genome may have deleterious effects on the offspring. The altered methylated status of these DMGs important for early development might modify their expression pattern and thus affect their function during key stages of embryogenesis, potentially leading to developmental disorders or miscarriages. This article is protected by copyright. All rights reserved.