[Biobanking in clinical trials involving multiple sclerosis patients].
Ekaterina M KamenskihA Yu KryginaS Ch GomboevaD ZhailebaevaD P KovalN A KicherovCh N OtchurzhapYu G BirulinaValentina M AlifirovaPublished in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2024)
Investigation of multiple sclerosis (MS) pathogenesis requires sophisticated analytical tools of precision medicine, such as omics research, which include genomics, microbiomics and metabolomics (proteomics, lipidomics and glycomics). Such sensitive methods are based on careful preanalytical work with biomaterials to maintain quality and obtain objective results. Implementation of biobanking as a universal method for working with biomaterials will help to standardize the stages of research, compare different scientific team's results. Collaboration of MS researchers with large biobanks can also help to conduct multicenter and long-term prospective studies, to include a wide number of patients. In this article, we analyze the experience of biobanking practice technologies in studies of MS patients and share the experience of partnership between the Center for MS of the Tomsk Region and the Bank of Biological Material of the Siberian State Medical University.
Keyphrases
- multiple sclerosis
- end stage renal disease
- mass spectrometry
- ejection fraction
- chronic kidney disease
- clinical trial
- newly diagnosed
- healthcare
- peritoneal dialysis
- ms ms
- prognostic factors
- primary care
- randomized controlled trial
- quality improvement
- white matter
- patient reported outcomes
- liquid chromatography
- study protocol
- patient reported
- tissue engineering
- phase ii