Neuropilin-1 promotes the oncogenic Tenascin-C/integrin β3 pathway and modulates chemoresistance in breast cancer cells.

Adviti NaikAida Al-YahyaeeNada AbdullahJuda-El SamNoura Al-ZeheimiMahmoud W YaishSirin A I Adham

Published in: BMC cancer (2018)

We thus report a novel mechanism correlating high baseline NRP-1 with upregulated TNC/ITGB3 signaling, but decreased ABCG2 expression, which sensitizes BT-474 NRP-1 cells to Adriamycin/Cyclophosphamide. The study emphasizes on the targetability of the NRP-1/ITGB3 axis and its potential as a predictive biomarker for chemotherapy response.

Keyphrases

induced apoptosis
breast cancer cells
poor prognosis
endoplasmic reticulum stress
cell cycle arrest
low dose
high dose
oxidative stress
signaling pathway
locally advanced
radiation therapy
rectal cancer