Biomaterials and Adipose-Derived Mesenchymal Stem Cells for Regenerative Medicine: A Systematic Review.
Vivian Alonso-GoulartLoyna Nobile CarvalhoAna Leticia Galante MarinhoBianca Lourenço de Oliveira SouzaGabriela de Aquino Pinto PalisHenrique Guerra Drumond LageIsabela Lemos de LimaLaura Duarte GuimarãesLucas Correia PeresMárcia Marques SilveiraGilberto Henrique Nogueira Lages LopesLorraine Braga FerreiraLetícia de Souza Castro FilicePublished in: Materials (Basel, Switzerland) (2021)
The use of biological templates for the suitable growth of adipose-derived mesenchymal stem cells (AD-MSC) and "neo-tissue" construction has exponentially increased over the last years. The bioengineered scaffolds still have a prominent and biocompatible framework playing a role in tissue regeneration. In order to supply AD-MSCs, biomaterials, as the stem cell niche, are more often supplemented by or stimulate molecular signals that allow differentiation events into several strains, besides their secretion of cytokines and effects of immunomodulation. This systematic review aims to highlight the details of the integration of several types of biomaterials used in association with AD-MSCs, collecting notorious and basic data of in vitro and in vivo assays, taking into account the relevance of the interference of the cell lineage origin and handling cell line protocols for both the replacement and repairing of damaged tissues or organs in clinical application. Our group analyzed the quality and results of the 98 articles selected from PubMed, Scopus and Web of Science. A total of 97% of the articles retrieved demonstrated the potential in clinical applications. The synthetic polymers were the most used biomaterials associated with AD-MSCs and almost half of the selected articles were applied on bone regeneration.
Keyphrases
- bone regeneration
- mesenchymal stem cells
- umbilical cord
- stem cells
- tissue engineering
- systematic review
- cell therapy
- single cell
- bone marrow
- public health
- meta analyses
- adipose tissue
- gene expression
- high throughput
- big data
- metabolic syndrome
- electronic health record
- artificial intelligence
- randomized controlled trial
- skeletal muscle
- single molecule