Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.

Anita FlorkowskaIgor MeszkaMagdalena ZawadaDiana LegutkoTomasz J ProszynskiKatarzyna Janczyk-IlachWladyslawa StreminskaMaria A CiemerychIwona Grabowska

Published in: Stem cell research & therapy (2020)

Pax7-/- ESCs differentiate in vivo to embryonic myoblasts more readily than Pax7+/+ cells. In the absence of functional Pax7, initiation of myogenic differentiation is facilitated, and as a result, the expression of mesoderm embryonic myoblast markers is upregulated. However, in the absence of functional Pax7 neuromuscular junctions, formation is abnormal, what results in lower differentiation potential of Pax7-/- ESCs during advanced stages of myogenesis.

Keyphrases

skeletal muscle
poor prognosis
single molecule
risk assessment
signaling pathway
long non coding rna
cell cycle arrest