Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases.
Claire J WigginsSusan Y ChonPublished in: Case reports in dermatological medicine (2020)
As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease. By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.
Keyphrases
- cell proliferation
- atopic dermatitis
- poor prognosis
- oxidative stress
- stem cells
- emergency department
- soft tissue
- combination therapy
- endoplasmic reticulum stress
- drug delivery
- rectal cancer
- cancer therapy
- wound healing
- replacement therapy
- bone marrow
- cell therapy
- minimally invasive
- adverse drug
- smoking cessation
- electronic health record