Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines.
Nasim SalimiaghdamLata SinghKevin SchneiderAngele NalbandianMarilyn ChwaShari R AtilanoAndrea BaoM Cristina KenneyPublished in: BMJ open ophthalmology (2020)
Clinically relevant concentrations of CPFX and TETRA have detrimental impacts on ARPE-19 cell lines in vitro, including upregulation of genes related to apoptosis, inflammation and antioxidant pathways. Additional studies are warranted to investigate if these harmful effects might be seen in retinal degeneration models in vivo.
Keyphrases
- oxidative stress
- optical coherence tomography
- diabetic retinopathy
- endoplasmic reticulum stress
- pseudomonas aeruginosa
- genome wide
- cell proliferation
- poor prognosis
- cell death
- cell cycle arrest
- signaling pathway
- anti inflammatory
- gene expression
- human health
- genome wide identification
- optic nerve
- dna methylation
- risk assessment
- visible light
- genome wide analysis