Adrenal suppression from vamorolone and prednisone in Duchenne muscular dystrophy: results from the phase 2b clinical trial.

Alexandra AhmetRebecca TobinUtkarsh J DangRaoul RoomanMichela GuglieriPaula R ClemensEric P HoffmanLeanne M Ward

Published in: The Journal of clinical endocrinology and metabolism (2024)

AS after vamorolone and prednisone was frequent and vamorolone-associated AS appeared dose-dependent. A lower stimulated cortisol threshold may be appropriate when using a monoclonal assay. We recommend hydrocortisone for glucocorticoid stress dosing in patients receiving vamorolone.

Keyphrases

duchenne muscular dystrophy
clinical trial
randomized controlled trial
study protocol
phase ii
double blind
stress induced
heat stress
septic shock