Two New Terpenoids from Talaromyces purpurogenus.
Wenjing WangXiao WanJun-Jun LiuJianping WangHucheng ZhuChunmei ChenYong-Hui ZhangPublished in: Marine drugs (2018)
A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol moiety, and roussoellol C possesses a novel tetracyclic fusicoccane framework with an unexpected hydroxyl at C-4. These new structures were confirmed by spectroscopic data, chemical method, NMR data calculations and electronic circular dichroism (ECD) calculations. The selected compounds were evaluated for cytotoxicities against five human cancer cell lines, including SW480, HL-60, A549, MCF-7, and SMMC-7721 and the IC50 values of compound 2 against MCF-7 and 3 against HL-60 cells were 6.5 and 7.9 μM, respectively.
Keyphrases
- density functional theory
- breast cancer cells
- electronic health record
- molecular dynamics
- molecular dynamics simulations
- induced apoptosis
- high resolution
- endothelial cells
- big data
- papillary thyroid
- molecular docking
- cell cycle arrest
- monte carlo
- signaling pathway
- squamous cell
- mass spectrometry
- squamous cell carcinoma
- endoplasmic reticulum stress
- cell proliferation
- artificial intelligence
- machine learning
- pluripotent stem cells
- solid state
- childhood cancer