Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.
Christian SchwartzTara MoranSean P SaundersAgnieszka KaszlikowskaAchilleas FloudasJoana BomGabriel NunezYoichiro IwakuraLuke Anthony John O'NeillAlan D IrvineAndrew N J McKenzieGraham S OggPatrick T WalshJocelyne DemengeotPadraic G FallonPublished in: Allergy (2019)
In summary, we identified a critical role for the microbiome and IL-1β mediating chronic inflammation in mice with an impaired skin barrier.