Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.
Fajri GafarRoeland E WasmannHelen M McIlleronRob E AarnoutsePawel T SchubertBen J MaraisDipti AgarwalSampson AntwiNguyen D BangAdrie BekkerDavid J BellChishala ChabalaLouise ChooGeraint R DaviesJeremy N DayRajeshwar DayalPaolo DentiPeter R DonaldEphrem EngidaworkAnthony J Garcia-PratsDiana GibbStephen M GrahamAnneke C HesselingScott K HeysellMisgana I IdrisSushil K KabraAarti KinikarAgibothu K Hemanth KumarAwewura KwaraRakesh LodhaCecile Magis-EscurraNilza MartinezBinu S MathewVidya MaveEstomih R MdumaRachel Mlotha-MitoleStellah G MpagamaAparna MukherjeeHeda M NataprawiraCharles A PeloquinThomas PouplinGeetha RamachandranJaya RanjalkarVandana RoyRovina RuslamiIra ShahYatish SinghMarieke G G SturkenboomElin M SvenssonSoumya SwaminathanUrmila ThatteStephanie TheeTania A ThomasTjokosela TikisoDaan J TouwAnna TurkovaThirumurthy VelpandianLilly M VerhagenJana L WincklerHongmei YangVycke YunivitaKatja TaxisJasper StevensJan-Willem C Alffenaarnull nullPublished in: The European respiratory journal (2022)
This study provides the most comprehensive estimates of plasma exposures to first-line antituberculosis drugs in children and adolescents. Key determinants of drug exposures were identified. These may be relevant for population-specific dose adjustment or individualised therapeutic drug monitoring.