Post-diagnosis serum insulin-like growth factors in relation to dietary and lifestyle changes in the Prostate testing for cancer and Treatment (ProtecT) trial.
Vanessa ErKalina BiernackaAndrew J SimpkinRichard M MartinMona JeffreysPauline EmmettRebecca GilbertKerry N L AveryEleanor WalshMichael DavisJenny L DonovanDavid E NealFreddie C HamdyJeff M P HollyJ Athene LanePublished in: Cancer causes & control : CCC (2017)
Decreased protein intake and body mass index, and increased physical activity and fruit and vegetable intake, following a prostate cancer diagnosis were associated with reduced post-diagnosis serum IGF-I and IGFBP-3. Counterintuitively, reduced fruit and vegetable intake was also associated with reduced IGF-I, but with weak statistical support, possibly implicating chance. If confirmed in other studies, our findings may inform potential lifestyle interventions in prostate cancer. ProtecT was registered at International Standard Randomised Controlled Trial Registry, http://isrctn.org as ISRCTN20141297.
Keyphrases
- prostate cancer
- physical activity
- radical prostatectomy
- study protocol
- type diabetes
- cardiovascular disease
- metabolic syndrome
- binding protein
- weight gain
- body mass index
- randomized controlled trial
- papillary thyroid
- cell proliferation
- climate change
- adipose tissue
- squamous cell carcinoma
- signaling pathway
- sleep quality
- risk assessment
- combination therapy
- human health
- benign prostatic hyperplasia
- protein protein
- case control
- childhood cancer