Increased cocaine-induced conditioned place preference during periadolescence in maternally separated male BALB/c mice: the role of cortical BDNF, microRNA-212, and MeCP2.

Thiago Wendt ViolaLuis Eduardo Wearick-SilvaLucas Araújo De AzeredoAnderson Centeno-SilvaConor MurphyPaul MarshallXiang LiNicolas SingewaldFrederico GarciaTimothy W BredyRodrigo Grassi-Oliveira

Published in: Psychopharmacology (2016)

Together, our results suggest that early life stress can enhance the motivational salience for cocaine-paired cues during periadolescence, and that altered expression of miR-212, Mecp2, and Bdnf in the prefrontal cortex is involved in this process.

Keyphrases

prefrontal cortex
early life
stress induced
poor prognosis
long non coding rna
cell proliferation
high glucose
diabetic rats
long noncoding rna
functional connectivity
high fat diet induced
drug induced
binding protein
oxidative stress
metabolic syndrome