Safety and Effectiveness of High-Intensity Statins Versus Low/Moderate-Intensity Statins Plus Ezetimibe in Patients With Atherosclerotic Cardiovascular Disease for Reaching LDL-C Goals: A Systematic Review and Meta-Analysis.

Hamidreza Soleimani Asma MousaviShayan ShojaeiKiarash TavakoliDorsa SalabatFarid Farahani RadMani K AskariJohn NelsonMohammad RuziehKaveh Hosseini

Published in: Clinical cardiology (2024)

Adding ezetimibe to low/moderate-intensity statins resulted in a greater reduction in LDL-C levels, a lower rate of myalgia, and less drug discontinuation compared to high-intensity statin monotherapy in patients with existing cardiovascular disease. However, according to our meta-analysis, the observed reduction in LDL-C levels in the combination group did not correlate with a reduction in MACE compared to the high-intensity statin group.

Keyphrases

high intensity
cardiovascular disease
systematic review
resistance training
low density lipoprotein
cardiovascular events
cardiovascular risk factors
type diabetes
randomized controlled trial
meta analyses
open label
adverse drug
electronic health record
case control