Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers.

Yanyuan WuMarianna SarkissyanOchanya OgahJuri KimJaydutt V Vadgama

Published in: Cancers (2020)

We show that MALAT1 contributes to HER2+ cell resistance to trastuzumab. Targeting the PI3/Akt pathway and stabilizing FOXO1 translocation could inhibit the upregulation of MALAT1.

Keyphrases

poor prognosis
signaling pathway
epidermal growth factor receptor
cell proliferation
metastatic breast cancer
single cell
cell therapy
pi k akt
cancer therapy
tyrosine kinase
drug delivery
young adults