Correlation between PlateletWorks® and PFA-100® for Measuring Platelet Function before Urgent Surgery in Patients with Chronic Antiplatelet Therapy.
Rafael AnayaMireia RodriguezJosé María GilNoelia VilaltaAngela Merchan-GalvisVictoria MoralJosé MateoMaría José Martinez-ZapataPublished in: Journal of clinical medicine (2021)
Hemostasis is crucial for reducing bleeding during surgical procedures. The points-of-care based on the platelet function test could be useful to minimize the complications related to chronic antiplatelet therapy during surgery. The present study is aimed at comparing two point-of-care platelet function devices-Platelet Function Analyzer PFA-100® (Siemens Canada, Mississauga, ON, Canada) and Plateletworks®(Helena Laboratories, Beaumont, TX, USA). Our objective is to evaluate if they provide comparable and useful information to manage anti-aggregate patients before surgery. We included patients with a femoral fracture receiving chronic antiplatelet therapy and a median age of 89 years (range from 70 to 98). A platelet function evaluation was performed on all patients before surgery using both devices-Plateletworks® and PFA-100®. The correlation between Plateletworks® and PFA-100® was performed using Cohen's Kappa coefficient. Twenty consecutive patients participated in the trial; 16 patients were under treatment with 75 mg/day of clopidogrel, three with >300 mg/day of acetylsalicylic acid (ASA), and only one was in treatment with both antiplatelet agents. Cohen's Kappa coefficient was 0.327 comparing PFA-100®-ADP (adenosine diphosphate) and Plateletworks® and, 0.200 comparing PFA-100®-EPI (epinephrine) and Plateletworks®. In conclusion, we found a weak concordance comparing PFA-100® and Plateletworks®. This could partially be due to the advanced age of the included patients. However, given the limited sample size, more studies are necessary to confirm these results.
Keyphrases
- antiplatelet therapy
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- acute coronary syndrome
- percutaneous coronary intervention
- prognostic factors
- healthcare
- randomized controlled trial
- computed tomography
- minimally invasive
- magnetic resonance imaging
- coronary artery bypass
- patient reported outcomes
- immune response
- combination therapy
- atrial fibrillation
- study protocol
- chronic pain
- social media
- smoking cessation
- replacement therapy