Effects of treatment with metformin and/or sitagliptin on beta-cell function and insulin resistance in prediabetic women with previous gestational diabetes.

Giuseppe DanieleAndrea TuraAngela DardanoAlessandra BertolottoCristina BianchiLaura GiustiJancy Joseph KurumthodathuStephano Del Prato

Published in: Diabetes, obesity & metabolism (2019)

This study shows that MET+SITA is superior to SITA and MET monotherapy regarding beta-cell function and insulin sensitivity improvement in IGR women with previous GDM, and may offer a potential pharmacologic intervention to reduce the risk of type 2 diabetes in this high-risk population.

Keyphrases

tyrosine kinase
randomized controlled trial
combination therapy
open label
risk assessment