Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain-A new treatment strategy for neonatal seizures?

Wiebke TheilmannClaudia BrandtBettina BohnhorstAnne-Mieke WinstrothAnibh Martin DasMartina GramerAndi KipperMarkus KalesseWolfgang Löscher

Published in: Epilepsia (2020)

These data provide a prerequisite for further evaluating the potential of bumetanide prodrugs as add-on therapy to phenobarbital and other antiseizure drugs as a new strategy for improving pharmacotherapy of neonatal seizures.

Keyphrases

endothelial cells
electronic health record
stem cells
machine learning
risk assessment
climate change
mesenchymal stem cells
drug delivery
data analysis
combination therapy