Wolfgang Löscher (W Löscher)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 43

Top Venues

Epilepsia

Cells

eNeuro

Biopharmaceutics & drug disposition

University of Veterinary Medicine

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Veterinary Medicine

Germany

Professor and Chair :: Department of Pharmacology

Publications

Wolfgang Löscher, Martina Gramer, Kerstin Römermann
Heterogeneous brain distribution of bumetanide following systemic administration in rats. Biopharmaceutics & drug disposition 45 (3) (2024)
Wolfgang Löscher
Of Mice and Men: The Inter-individual Variability of the Brain's Response to Drugs. eNeuro 11 (2) (2024)
Wolfgang Löscher
Of Mice and Men: The Inter-individual Variability of the Brain's Response to Drugs. eNeuro 11 (2) (2024)
Pavel Klein, Rafal M Kaminski, Matthias J Koepp, Wolfgang Löscher
New epilepsy therapies in development. Nature reviews. Drug discovery (2024)
Wolfgang Löscher, Martina Gramer, Kerstin Römermann
Heterogeneous brain distribution of bumetanide following systemic administration in rats. Biopharmaceutics & drug disposition (2024)
Wolfgang Löscher, Martina Gramer, Kerstin Römermann
Heterogeneous brain distribution of bumetanide following systemic administration in rats. Biopharmaceutics & drug disposition 45 (3) (2024)
Wolfgang Löscher
Of Mice and Men: The Inter-individual Variability of the Brain's Response to Drugs. eNeuro 11 (2) (2024)
Chris Rundfeldt, Pavel Klein, Detlev Boison, Alexander Rotenberg, Raimondo D'Ambrosio, Cliff Eastman, Benton Purnell, Madhuvika Murugan, Howard P Goodkin, Wolfgang Löscher
Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus. Epilepsia (2023)
Wolfgang Löscher
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy? Epilepsia (2023)
Wolfgang Löscher
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy? Epilepsia 64 (3) (2023)
Wolfgang Löscher
On hidden factors and design-associated errors that may lead to data misinterpretation - an example from preclinical research on the potential seasonality of neonatal seizures. Epilepsia (2023)
Wolfgang Löscher
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy? Epilepsia 64 (3) (2023)
Wolfgang Löscher, H Steve White
Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments. Cells 12 (9) (2023)
Wolfgang Löscher
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy? Epilepsia (2023)
Chris Rundfeldt, Pavel Klein, Detlev Boison, Alexander Rotenberg, Raimondo D'Ambrosio, Cliff Eastman, Benton Purnell, Madhuvika Murugan, Howard P Goodkin, Wolfgang Löscher
Preclinical pharmacokinetics and tolerability of a novel meglumine-based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus. Epilepsia (2023)
Wolfgang Löscher
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy? Epilepsia 64 (3) (2023)
Wolfgang Löscher, H Steve White
Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments. Cells 12 (9) (2023)
Wolfgang Löscher, H Steve White
Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments. Cells 12 (9) (2023)
Wolfgang Löscher
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy? Epilepsia 64 (3) (2023)
Björn Gailus, Ricardo Schmidt, Marie Johne, Wolfgang Löscher
Midazolam prevents the adverse outcome of neonatal asphyxia. Annals of neurology (2022)
Kai Kaila, Wolfgang Löscher
Bumetanide for neonatal seizures: No light in the pharmacokinetic/dynamic tunnel. Epilepsia 63 (7) (2022)
Birthe Gericke, Inka Wienböker, Gudrun Brandes, Wolfgang Löscher
Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver. Cells 11 (9) (2022)
Wolfgang Löscher, Carl E Stafstrom
Epilepsy and its neurobehavioral comorbidities: Insights gained from animal models. Epilepsia (2022)
Marie Johne, Christopher Käufer, Kerstin Römermann, Björn Gailus, Birthe Gericke, Wolfgang Löscher
A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia. Epilepsia 62 (6) (2021)
Birthe Gericke, Saskia Borsdorf, Inka Wienböker, Andreas Noack, Sandra Noack, Wolfgang Löscher
Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines. Fluids and barriers of the CNS 18 (1) (2021)
Wolfgang Löscher, Pavel Klein
The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond. CNS drugs 35 (9) (2021)
Wolfgang Löscher, Graeme J Sills, H Steve White
The ups and downs of alkyl-carbamates in epilepsy therapy: How does cenobamate differ? Epilepsia 62 (3) (2021)
Wolfgang Löscher, Kai Kaila
Reply to the commentary by Ben-Ari and Delpire: Bumetanide and neonatal seizures: Fiction versus reality. Epilepsia 62 (4) (2021)
Aristea S Galanopoulou, Wolfgang Löscher, Laura Lubbers, Terence J O'Brien, Kevin Staley, Annamaria Vezzani, Raimondo D'Ambrosio, H Steve White, Harald Sontheimer, John A Wolf, Roy Twyman, Vicky Whittemore, Karen S Wilcox, Brian Klein
Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop. Epilepsia open 6 (2) (2021)
Björn Gailus, Hannah Naundorf, Lisa Welzel, Marie Johne, Kerstin Römermann, Kai Kaila, Wolfgang Löscher
Long-term outcome in a noninvasive rat model of birth asphyxia with neonatal seizures: Cognitive impairment, anxiety, epilepsy, and structural brain alterations. Epilepsia 62 (11) (2021)
Pavel Klein, Alon Friedman, Mustafa Q Hameed, Rafal M Kaminski, Guy Bar-Klein, Henrik Klitgaard, Mathias Koepp, Sergiusz Jozwiak, David A Prince, Alexander Rotenberg, Roy Twyman, Annamaria Vezzani, Michael Wong, Wolfgang Löscher
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? Epilepsia 61 (3) (2020)
Wolfgang Löscher, Alon Friedman
Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both? International journal of molecular sciences 21 (2) (2020)
Wiebke Theilmann, Claudia Brandt, Bettina Bohnhorst, Anne-Mieke Winstroth, Anibh Martin Das, Martina Gramer, Andi Kipper, Markus Kalesse, Wolfgang Löscher
Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain-A new treatment strategy for neonatal seizures? Epilepsia 62 (1) (2020)
Marie Johne, Kerstin Römermann, Philip Hampel, Björn Gailus, Wiebke Theilmann, Tommi Ala-Kurikka, Kai Kaila, Wolfgang Löscher
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. Epilepsia 62 (4) (2020)
Birthe Gericke, Kerstin Römermann, Andreas Noack, Sandra Noack, Jessica Kronenberg, Ingolf Ernst Blasig, Wolfgang Löscher
A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies. Fluids and barriers of the CNS 17 (1) (2020)
Konrad J Dębski, Nicholas Ceglia, Antoine Ghestem, Anton I Ivanov, Giulio Emilio Brancati, Sonja Bröer, A M Bot, Johannes Alexander Müller, Susanne Schoch, A Becker, Wolfgang Löscher, M Guye, Carolina Magdalen Greco, Katarzyna Łukasiuk, P Baldi, Christophe Bernard
The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy. Science advances 6 (41) (2020)
Wolfgang Löscher, Birthe Gericke
Novel Intrinsic Mechanisms of Active Drug Extrusion at the Blood-Brain Barrier: Potential Targets for Enhancing Drug Delivery to the Brain? Pharmaceutics 12 (10) (2020)
Wolfgang Löscher
Consequences of housing conditions and interindividual diversity in rodent models of acquired epilepsy. Epilepsia 60 (10) (2019)
Lisa Welzel, Alina Schidlitzki, Friederike Twele, Muneeb Anjum, Wolfgang Löscher
A face-to-face comparison of the intra-amygdala and intrahippocampal kainate mouse models of mesial temporal lobe epilepsy and their utility for testing novel therapies. Epilepsia 61 (1) (2019)
Andreas Noack, Birthe Gericke, Maren von Köckritz-Blickwede, Arne Menze, Sandra Noack, Ingo Gerhauser, Felix Osten, Hassan Y Naim, Wolfgang Löscher
Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils. Proceedings of the National Academy of Sciences of the United States of America 115 (41) (2018)
Christopher Käufer, Chintan Chhatbar, Sonja Bröer, Inken Waltl, Luca Ghita, Ingo Gerhauser, Ulrich Kalinke, Wolfgang Löscher
Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures. Proceedings of the National Academy of Sciences of the United States of America 115 (38) (2018)
Alexandra Neyazi, Wiebke Theilmann, Claudia Brandt, Tomi Rantamäki, Nobuaki Matsui, Mathias Rhein, Johannes Kornhuber, Malek Bajbouj, Wolfgang Sperling, Stefan Bleich, Helge Frieling, Wolfgang Löscher
P11 promoter methylation predicts the antidepressant effect of electroconvulsive therapy. Translational psychiatry 8 (1) (2018)
Pavel Klein, Raymond Dingledine, Eleonora Aronica, Christophe Bernard, Ingmar Bluemcke, Detlev Boison, Martin J Brodie, Amy R Brooks-Kayal, Jerome Engel, Patrick A Forcelli, Lawrence J Hirsch, Rafal M Kaminski, Henrik Klitgaard, Katja Kobow, Daniel H Lowenstein, Phillip L Pearl, Asla Pitkänen, Noora Puhakka, Michael A Rogawski, Dieter Schmidt, Matti Sillanpää, Robert S Sloviter, Christian Steinhäuser, Annamaria Vezzani, Matthew C Walker, Wolfgang Löscher
Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia 59 (1) (2017)

Wolfgang Löscher.css-eqlu8i{font-size:small;padding-left:4px;} (W Löscher)

Publication Activity (10 Years)

Top Topics

Top Venues

Wolfgang Löscher (W Löscher)