miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts.

Li LuoLu YaoYoulong XieEnxiang ChenYubin DingLu-Xing Ge

Published in: Journal of assisted reproduction and genetics (2023)

Thus, miR-526b-5p affected the proliferation, migration, and invasion of trophoblasts by targeting c-Myc and Foxp1. Low expression of c-Myc further deactivated the positive transcriptional regulation of c-Myc on Foxp1, which may be the mechanism of RSA. This study provides potential therapeutic targets and clues for the diagnosis and treatment of RSA.

Keyphrases

regulatory t cells
signaling pathway
poor prognosis
dendritic cells
binding protein
human health
immune response
risk assessment
climate change