Brain Temperature as an Indicator of Cognitive Function in Traumatic Brain Injury Patients.
Maho KitagawaKagari AbikoSulaiman SheriffAndrew A MaudsleyXinnan LiDaisuke SawamuraSinyeob AhnKhin Khin ThaPublished in: Metabolites (2023)
Whether brain temperature noninvasively extracted by magnetic resonance imaging has a role in identifying brain changes in the later phases of mild to moderate traumatic brain injury (TBI) is not known. This prospective study aimed to evaluate if TBI patients in subacute and chronic phases had altered brain temperature measured by whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) and if the measurable brain temperature had any relationship with cognitive function scores. WB-MRSI was performed on eight TBI patients and fifteen age- and sex-matched control subjects. Brain temperature (T) was extracted from the brain's major metabolites and compared between the two groups. The T of the patients was tested for correlation with cognitive function test scores. The results showed significantly lower brain temperature in the TBI patients ( p < 0.05). Brain temperature derived from N-acetylaspartate (T NAA ) strongly correlated with the 2 s paced auditory serial addition test (PASAT-2s) score ( p < 0.05). The observation of lower brain temperature in TBI patients may be due to decreased metabolic activity resulting from glucose and oxygen depletion. The correlation of brain temperature with PASAT-2s may imply that noninvasive brain temperature may become a noninvasive index reflecting cognitive performance.
Keyphrases
- traumatic brain injury
- end stage renal disease
- resting state
- white matter
- chronic kidney disease
- magnetic resonance imaging
- newly diagnosed
- magnetic resonance
- ejection fraction
- functional connectivity
- prognostic factors
- peritoneal dialysis
- multiple sclerosis
- cerebral ischemia
- type diabetes
- ms ms
- patient reported outcomes
- adipose tissue
- working memory
- severe traumatic brain injury
- insulin resistance
- skeletal muscle
- weight loss
- blood brain barrier
- mild traumatic brain injury