Systematic review of genetic association studies in people with Lewy body dementia.
Hazel SanghviRicky SinghHamilton MorrinAnto P RajkumarPublished in: International journal of geriatric psychiatry (2020)
The reported genetic associations and their potential interactions indicate the importance of α-synuclein, amyloid, and tau pathology, autophagy lysosomal pathway, ubiquitin proteasome system, oxidative stress, and mitochondrial dysfunction in LBD. There is a need for larger genome-wide association study (GWAS) for identifying more LBD-associated genes. Future hypothesis-driven studies should aim to replicate reported genetic associations of LBD and to explore their functional implications.
Keyphrases
- genome wide
- systematic review
- genome wide association study
- oxidative stress
- copy number
- dna methylation
- meta analyses
- mild cognitive impairment
- dna damage
- case control
- signaling pathway
- endoplasmic reticulum stress
- cerebrospinal fluid
- randomized controlled trial
- cognitive impairment
- gene expression
- current status
- climate change
- heat shock