Early embryonic arrest and fragmentation (EEAF) is a common phenotype observed in in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. The phenotype causes female infertility and recurrent failed IVF/ICSI attempts. However, the molecular mechanisms behind EEAF remain largely unknown. In this issue of EMBO Molecular Medicine, Zhang et al (2021) present the novel causative gene MOS in patients with the EEAF phenotype. The relationship between MOS variants and human EEAF is comprehensively established through a series of in vitro and in vivo experiments, thus clarifying the role of MOS during human oocyte maturation and early embryo development. These findings suggest that MOS is a new diagnostic marker of EEAF and is a potential therapeutic target for treatment of EEAF patients.
Keyphrases
- endothelial cells
- quantum dots
- room temperature
- pregnancy outcomes
- induced pluripotent stem cells
- reduced graphene oxide
- end stage renal disease
- pluripotent stem cells
- copy number
- highly efficient
- chronic kidney disease
- genome wide
- newly diagnosed
- cell cycle
- visible light
- pregnant women
- transition metal
- gene expression
- skeletal muscle
- dna methylation
- metabolic syndrome
- climate change
- prognostic factors
- polycystic ovary syndrome
- human health