Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.

Austin M ReillyShudi ZhouSunil K PanigrahiShijun YanJason M ConleyPatrick L SheetsSharon L WardlawHongxia Ren

Published in: Nutrition & diabetes (2019)

Gpr17 deficiency in POMC neurons protects metabolic homeostasis in a sex-dependent manner during dietary and aging challenges, suggesting that Gpr17 could be an effective anti-obesity target in specific populations with poor metabolic control.

Keyphrases

high fat diet
insulin resistance
fatty acid
adipose tissue
spinal cord
metabolic syndrome
type diabetes
weight loss
replacement therapy
weight gain
high fat diet induced
body mass index
physical activity