Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii -stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway.
Chen ShuZhang Yan-YanZhang HaiDing Long-KunXi YueYan ManSun ChangLiang WuHu HaoPublished in: Acta pharmaceutica (Zagreb, Croatia) (2022)
This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on Acinetobacter baumannii -induced THP-1 cells. The three main SCFAs could inhibit A. baumannii -stimulated THP-1 cell NF-κB pathway activity and the expressions of NLRP3 inflamma-some and GSDMD, and increase autophagy. The three main SCFAs, especially the sodium butyrate (NaB), had the effect of down-regulation of ROS and TLR-2 expression in THP-1 cells. NaB and sodium propionate (NaPc), but not sodium acetate (NaAc), dramatically suppressed IL-1β and IFN-γ expression. The results indicated that NaB and NaPc could significantly inhibit the inflammation of THP-1 cells induced by A. baumannii , and the inhibitory effect was in the order of NaB > NaPc > NaAC. NaB and NaPc may inhibit inflammation through TLR-2/NF-κB/ROS/NLRP3 signaling pathway.
Keyphrases
- induced apoptosis
- signaling pathway
- oxidative stress
- acinetobacter baumannii
- cell cycle arrest
- pi k akt
- cell death
- multidrug resistant
- advanced non small cell lung cancer
- drug resistant
- endoplasmic reticulum stress
- toll like receptor
- pseudomonas aeruginosa
- inflammatory response
- dna damage
- nuclear factor
- poor prognosis
- lps induced
- epithelial mesenchymal transition
- cell proliferation
- cystic fibrosis
- reactive oxygen species
- cell therapy
- single cell
- diabetic rats
- tyrosine kinase
- binding protein