An In Vitro Study on the Interactions of Pycnogenol® with Cisplatin in Human Cervical Cancer Cells.

Merve Becit Kizilkaya Sevtap Aydın Dilsiz

Published in: Turkish journal of pharmaceutical sciences (2020)

Our results suggest that PYC may increase the cisplatin cytotoxicity in HeLa cells at nongenotoxic doses. The results might contribute to the anticancer effect of cisplatin with PYC in cervical carcinoma, but in order to confirm this result further in vitro studies with cancer cell lines and in vivo studies are needed.

Keyphrases

cell cycle arrest
induced apoptosis
endothelial cells
case control
papillary thyroid
induced pluripotent stem cells
squamous cell
signaling pathway
cell proliferation
pluripotent stem cells
young adults