Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney.

Keri A DrakeChristopher ChaneyMohita PatelAmrita DasJulia M Bittencourt Martin J Cohn Thomas J Carroll

Published in: Journal of the American Society of Nephrology : JASN (2022)

These findings reveal a critical role for YAP/TAZ in specific embryonic stromal cells and suggest that interaction with cofactors, such as SRF, influence the expression of cell type-specific target genes, thus driving stromal heterogeneity. Further, this work reveals functional roles for renal stroma heterogeneity in creating unique microenvironments that influence the differentiation and maintenance of the renal parenchyma.

Keyphrases

single cell
transcription factor
poor prognosis
bone marrow
gene expression
genome wide identification