Gamma-aminobutyric acidergic transmission underlies interictal epileptogenicity in pediatric focal cortical dysplasia.

Thomas BlauwblommeElena DossiChristophe PellegrinoEmmanuelle GoubertBeatriz Gal IglesiasChristian Sainte-RoseNathalie RouachRima NabboutGilles Huberfeld

Published in: Annals of neurology (2019)

Altered chloride cotransporter expression and changes in interneuron density in FCD may lead to paradoxical depolarization of pyramidal cells. Spontaneous interictal discharges are consequently mediated by GABAergic signals, and targeting chloride regulation in neurons may be considered for the development of new antiepileptic drugs. Ann Neurol 2019; 1-14 ANN NEUROL 2019;85:204-217.

Keyphrases

induced apoptosis
poor prognosis
neural network
cell cycle arrest
spinal cord
cancer therapy
temporal lobe epilepsy
binding protein
oxidative stress
spinal cord injury