Increased infiltration of CCR4-positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis.
Masahito WatanabeKent KanaoSusumu SuzukiHiroyuki MuramatsuSingo MorinagaKeishi KajikawaIkuo KobayashiGenya NishikawaYoshiharu KatoKenji ZennamiKogenta NakamuraToyonori TsuzukiKazuhiro YoshikawaRyuzo UedaMakoto SumitomoPublished in: The Prostate (2019)
CCR4+Tregs are highly infiltrated in the prostate tissue of patients with poor prognosis with potential to progress to CRPC. Furthermore, the degree of infiltration of CCR4+Tregs is related to the prognosis of prostate cancer.