New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma   brevicompactum .

Eight trichothecenes, including four new compounds 1 - 4 and four known entities 5 - 8 , together with one known cyclonerane ( 9 ) were isolated from the solid-state fermentation of Trichoderma   brevicompactum NTU439 isolated from the marine alga Mastophora rosea . The structures of 1 - 9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC 50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 μM, respectively. Compounds 1 - 2 , 4 - 6 , and 7 - 8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.