Empirical metronidazole for patients with severe bacterial infection: A systematic review with meta-analysis and trial sequential analysis.

Marie Warrer Munch Anders Perner Andreas Bender JonssonMarjan BahadorFredrik SjövallMorten Hylander Möller

Published in: Acta anaesthesiologica Scandinavica (2019)

There is low quantity and quality of evidence supporting the use of empirical metronidazole in adult patients with severe bacterial infections of any origin, and no firm evidence for benefit or harm.

Keyphrases

early onset
clinical trial
study protocol
phase iii
drug induced
randomized controlled trial
open label