Valproic Acid Inhibits NA-K-2CL Cotransporter RNA Expression in Male But Not in Female Rat Thymocytes.

Milda JuknevičienėIngrida BalnytėAngelija ValančiūtėVaiva LesauskaitėJurate StanevičiūtėRūta CurkūnavičiūtėDonatas Stakišaitis

Published in: Dose-response : a publication of International Hormesis Society (2019)

The study showed a gender-related difference in the NKCC1 RNA expression in rat thymus. The VPA decreases the NKCC1 expression in the thymus only in gonad-intact male rats. The NKCC1 RNA expression downregulation by VPA could be important for further VPA pharmacological studies in oncology.

Keyphrases

poor prognosis
binding protein
long non coding rna
palliative care
signaling pathway
nucleic acid
case control