Effects of platelet dysfunction and platelet transfusion on outcomes in traumatic brain injury patients.
Andrew R GuillotteJoseph P HerbertRichard MadsenRichard D HammerN Scott LitofskyPublished in: Brain injury (2018)
Mild TBI results in less ADP inhibition compared to moderate and severe TBI, suggesting a dose response relationship between TBI severity and degree of platelet dysfunction. Further, study is warranted to determine efficacy and parameters for platelet transfusion in patients with TBI.
Keyphrases
- traumatic brain injury
- severe traumatic brain injury
- end stage renal disease
- cardiac surgery
- oxidative stress
- ejection fraction
- mild traumatic brain injury
- chronic kidney disease
- prognostic factors
- sickle cell disease
- peritoneal dialysis
- type diabetes
- early onset
- acute kidney injury
- adipose tissue
- patient reported outcomes
- insulin resistance
- weight loss
- drug induced