Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation.
José Ignacio Veytia-BucheliJuana María Jiménez-VargasErika Isabel Melchy-PérezMonserrat Alba Sandoval-HernándezLourival Domingos PossaniYvonne RosensteinPublished in: Cell communication and signaling : CCS (2018)
The Vm24 toxin, a highly specific inhibitor of Kv1.3 channels allowed us to define downstream functions of the Kv1.3 channels in human CD4+ TEM lymphocytes. Blocking Kv1.3 channels profoundly affects the mRNA synthesis machinery, the unfolded protein response and the intracellular vesicle transport, impairing the synthesis and secretion of cytokines in response to TCR engagement, underscoring the role of Kv1.3 channels in regulating TEM lymphocyte function.