CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma.

Akira YorozuShohei SekiguchiAkira TakasawaFumika OkazakiTakeshi NiinumaHiroshi KitajimaEiichiro YamamotoMasahiro KaiMutsumi ToyotaYui HatanakaKoyo NishiyamaKazuhiro OgiHironari DehariKazufumi ObataMakoto KuroseAtsushi KondoMakoto OsanaiAkihiro MiyazakiKenichi TakanoHiromu Suzuki

Published in: Cancer medicine (2022)

Our results suggest that tongue OSCC cells activate CXCL12 expression in muscle cells, which may contribute to tumor progression. However, CXCL12 is reduced in advanced OSCCs due to muscle tissue destruction.

Keyphrases

induced apoptosis
skeletal muscle
cell cycle arrest
poor prognosis
type diabetes
endoplasmic reticulum stress
signaling pathway
cell death
insulin resistance
oxidative stress