Predictors of long-term disability accrual in relapse-onset multiple sclerosis.
Vilija G JokubaitisTim SpelmanTomas KalincikJohannes LorscheiderEva HavrdovaDana HorakovaPierre DuquetteMarc GirardAlexandre PratGuillermo IzquierdoPierre GrammondVincent Van PeschEugenio PucciFrançois Grand'MaisonRaymond HuppertsFranco GranellaPatrizia SolaRoberto BergamaschiGerardo IulianoDaniele SpitaleriCavit BozSuzanne HodgkinsonJavier OlascoagaFreek VerheulPamela McCombeThor PetersenCsilla RozsaJeannette Lechner-ScottMaria Laura SaladinoDeborah FarinaPietro IaffaldanoDamiano PaolicelliHelmut ButzkuevenAlessandra LugaresiMaria Trojanonull nullPublished in: Annals of neurology (2016)
We provide evidence of long-term treatment benefit in a large registry cohort, and provide evidence of long-term protective effects of pregnancy against disability accrual. We demonstrate that high annualized relapse rate, particularly on-treatment relapse, is an indicator of poor prognosis. Ann Neurol 2016;80:89-100.