MSCs Contribute to the Conversion of Ly6Chigh Monocytes into Ly6Clow Subsets under AMI.

Wenbin LuGenshan MaZulong ShengQingjie WangLijuan ChenJunhua QiRonghui ShiJingjing JiZhenjun JiQiming Dai

Published in: Stem cells international (2020)

MSCs can control the heterogeneity of Ly6Chigh monocyte differentiation into Ly6Clow monocytes and further reduce inflammation after AMI. The underlying mechanism might be that MSCs contribute to the increased expression of NR4A1 in Ly6Chigh/low monocytes.

Keyphrases

peripheral blood
mesenchymal stem cells
dendritic cells
acute myocardial infarction
umbilical cord
poor prognosis
oxidative stress
single cell
heart failure
immune response
percutaneous coronary intervention